Tg-SwDI Transgenic Mice Exhibit Novel Alterations in AβPP Processing, Aβ Degradation, and Resilient Amyloid Angiopathy

Alzheimer’s disease (AD) is characterized by the accumulation of extracellular insoluble amyloid, primarily derived from polymerized amyloid-β (Aβ) peptides. We characterized the chemical composition of the Aβ peptides deposited in the brain parenchyma and cerebrovascular walls of triple transgenic...

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Autors principals: Van Vickle, Gregory D., Esh, Chera L., Daugs, Ian D., Kokjohn, Tyler A., Kalback, Walter M., Patton, R. Lyle, Luehrs, Dean C., Walker, Douglas G., Lue, Lih-Fen, Beach, Thomas G., Davis, Judianne, Van Nostrand, William E., Castaño, Eduardo M., Roher, Alex E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2008
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475785/
https://ncbi.nlm.nih.gov/pubmed/18599612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071191
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