Tg-SwDI Transgenic Mice Exhibit Novel Alterations in AβPP Processing, Aβ Degradation, and Resilient Amyloid Angiopathy

Alzheimer’s disease (AD) is characterized by the accumulation of extracellular insoluble amyloid, primarily derived from polymerized amyloid-β (Aβ) peptides. We characterized the chemical composition of the Aβ peptides deposited in the brain parenchyma and cerebrovascular walls of triple transgenic...

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Detalhes bibliográficos
Main Authors: Van Vickle, Gregory D., Esh, Chera L., Daugs, Ian D., Kokjohn, Tyler A., Kalback, Walter M., Patton, R. Lyle, Luehrs, Dean C., Walker, Douglas G., Lue, Lih-Fen, Beach, Thomas G., Davis, Judianne, Van Nostrand, William E., Castaño, Eduardo M., Roher, Alex E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475785/
https://ncbi.nlm.nih.gov/pubmed/18599612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071191
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