Mitogen-activated Protein Kinase Phosphatase-1 Represses c-Jun NH(2)-terminal Kinase-mediated Apoptosis via NF-κB Regulation

The mechanism regulating radiation-induced anti-apoptotic response, a limiting factor in improving cell radiosensitivity, remains elusive. Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is the major member of MKPs that dephosphorylates and inactivates MAPK. Here we provide the evidence...

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Hlavní autoři: Wang, Zhaoqing, Cao, Ning, Nantajit, Danupon, Fan, Ming, Liu, Yusen, Li, Jian Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475689/
https://ncbi.nlm.nih.gov/pubmed/18508759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802229200
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