Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA

The selective degradation of mutated mitochondrial DNA (mtDNA) molecules is a potential strategy to re-populate cells with wild-type (wt) mtDNA molecules and thereby alleviate the defective mitochondrial function that underlies mtDNA diseases. Zinc finger nucleases (ZFNs), which are nucleases conjug...

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Bibliografiska uppgifter
Huvudupphovsmän: Minczuk, Michal, Papworth, Monika A., Miller, Jeffrey C., Murphy, Michael P., Klug, Aaron
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2008
Ämnen:
Nucleic Acid Enzymes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475635/
https://ncbi.nlm.nih.gov/pubmed/18511461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn313
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