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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase
We used engineered zinc finger peptides (ZFPs) to bind selectively to predetermined sequences in human mtDNA. Surprisingly, we found that engineered ZFPs cannot be reliably routed to mitochondria by using only conventional mitochondrial targeting sequences. We here show that addition of a nuclear ex...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1750892/ https://ncbi.nlm.nih.gov/pubmed/17170133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609502103 |
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