Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes

Gene silencing by targeted DNA methylation has potential applications in basic research and therapy. To establish targeted methylation in human cell lines, the catalytic domains (CDs) of mouse Dnmt3a and Dnmt3b DNA methyltransferases (MTases) were fused to different DNA binding domains (DBD) of GAL4...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Fuyang, Papworth, Monika, Minczuk, Michal, Rohde, Christian, Zhang, Yingying, Ragozin, Sergei, Jeltsch, Albert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2007
Pynciau:
Nucleic Acid Enzymes
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1761428/
https://ncbi.nlm.nih.gov/pubmed/17151075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1035
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