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Triplex-forming oligonucleotide–orthophenanthroline conjugates for efficient targeted genome modification
The inefficiency of gene modification by homologous recombination can be overcome by the introduction of a double-strand break (DSB) in the target. Engineering the endonucleases needed, however, remains a challenging task that limits widespread application of nuclease-driven gene modification. We re...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474501/ https://ncbi.nlm.nih.gov/pubmed/18599454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710433105 |
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