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Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
Klotho is a mammalian senescence-suppression protein that has homology with glycosidases. The extracellular domain of Klotho is secreted into urine and blood and may function as a humoral factor. Klotho-deficient mice have accelerated aging and imbalance of ion homeostasis. Klotho treatment increase...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474477/ https://ncbi.nlm.nih.gov/pubmed/18606998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803223105 |
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