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Bioinformatic method for protein thermal stabilization by structural entropy optimization
Engineering proteins for higher thermal stability is an important and difficult challenge. We describe a bioinformatic method incorporating sequence alignments to redesign proteins to be more stable through optimization of local structural entropy. Using this method, improved configurational entropy...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474475/ https://ncbi.nlm.nih.gov/pubmed/18621726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800938105 |
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