Anti-Aβ single chain antibody delivery via adeno-associated virus for treatment of Alzheimer’s disease

Immunization of mouse models of Alzheimer disease (AD) with amyloid-peptide (Aβ) reduces Aβ deposits and attenuates their memory and learning deficits. Recent clinical trials were halted due to meningoencephalitis, presumably induced by T cell mediated and/or Fc-mediated immune responses. Because in...

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Detalhes bibliográficos
Main Authors: Fukuchi, Ken-ichiro, Tahara, Kazuki, Kim, Hong-Duck, Maxwell, J. Adam, Lewis, Terry. L., Accavitti-Loper, Mary Ann, Kim, Helen, Ponnazhagan, Selvarangan, Lalonde, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459226/
https://ncbi.nlm.nih.gov/pubmed/16766200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2006.04.012
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