Total Syntheses of (±)-Ovalicin, C4(S*)-Isomer, and Its C5-Analogs and Anti-trypanosomal Activities

Total syntheses of (±)-ovalicin, its C4(S*)-isomer 44, and C5-side chain intermediate 46 were accomplished via an intramolecular Heck reaction of (Z)-3-(t-butyldimethylsilyloxy)-1-iodo-1,6-heptadiene and a catalytic amount of palladium acetate. Subsequent epoxidation, dihydroxylation, methylation an...

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Main Authors: Hua, Duy H., Zhao, Huiping, Battina, Srinivas K., Lou, Kaiyan, Jimenez, Ana L., Desper, John, Perchellet, Elisabeth M., Perchellet, Jean-Pierre H., Chiang, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453514/
https://ncbi.nlm.nih.gov/pubmed/18356059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.03.009
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