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Syntheses and biological evaluation of ring-C modified colchicine analogs
Ring-C modified alkaloids were synthesized from colchicine using iminonitroso Diels–Alder reactions in a highly regio-and stereoselective fashion. Several analogs exhibited cytotoxic activity similar to that of colchicine itself against PC-3 and MCF-7 cancer cell lines, by serving as prodrugs of col...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883562/ https://ncbi.nlm.nih.gov/pubmed/20529690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.03.056 |
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