Inhibition by quinolones of DNA gyrase from Staphylococcus aureus.
In order to clarify the mechanism of action of quinolones against Staphylococcus aureus, the subunit A and B proteins of DNA gyrase were separately purified from a crude extract of S. aureus FDA 209-P. The reconstituted enzyme exhibited ATP-dependent DNA supercoiling activity. The inhibitory effects...
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| Veröffentlicht in: | Antimicrob Agents Chemother |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
1991
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245197/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1656864/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.7.1489 |
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