Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

Cytochrome c release and the mitochondrial permeability transition (PT), including loss of the transmembrane potential (Δψ), play an important role in apoptosis. Using isolated mitochondria, we found that recombinant Bax and Bak, proapoptotic members of the Bcl-2 family, induced mitochondrial Δψ los...

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Autores principales: Narita, Masashi, Shimizu, Shigeomi, Ito, Toshinori, Chittenden, Thomas, Lutz, Robert J., Matsuda, Hikaru, Tsujimoto, Yoshihide
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC24509/
https://ncbi.nlm.nih.gov/pubmed/9843949
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