Mitochondrial Permeability Transition Pore: The Cardiovascular Disease’s Molecular Achilles Heel

The mitochondrial permeability transition pore (mPTP) plays a central role in myocardial injury. Upon reperfusion after myocardial infarction, oxidative stress, calcium overload, and ATP depletion promote mPTP opening, leading to mitochondrial dysfunction, cell death, and infarct expansion. This pro...

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Détails bibliographiques

Auteurs principaux:	Salvatore Nesci, Speranza Rubattu
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2025-12-01
Collection:	Biomedicines
Sujets:	cardiovascular diseases mitochondria myocardial infarction mitochondrial permeability transition pore cell death
Accès en ligne:	https://www.mdpi.com/2227-9059/13/12/3014
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