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Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin

NMR investigations have been carried out of complexes between bovine chymotrypsin A(α) and a series of four peptidyl trifluoromethyl ketones, listed here in order of increasing affinity for chymotrypsin: N-Acetyl-l-Phe-CF(3), N-Acetyl-Gly-l-Phe-CF(3), N-Acetyl-l-Val-l-Phe-CF(3), and N-Acetyl-l-Leu-l...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Lin, Jing, Westler, William M., Cleland, W. Wallace, Markley, John L., Frey, Perry A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1998
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843946/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14664
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