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Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin

NMR investigations have been carried out of complexes between bovine chymotrypsin A(α) and a series of four peptidyl trifluoromethyl ketones, listed here in order of increasing affinity for chymotrypsin: N-Acetyl-l-Phe-CF(3), N-Acetyl-Gly-l-Phe-CF(3), N-Acetyl-l-Val-l-Phe-CF(3), and N-Acetyl-l-Leu-l...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Lin, Jing, Westler, William M., Cleland, W. Wallace, Markley, John L., Frey, Perry A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843946/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14664
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