The Nalp3 inflammasome is essential for the development of silicosis

Inhalation of crystalline silica and asbestos is known to cause the progressive pulmonary fibrotic disorders silicosis and asbestosis, respectively. Although alveolar macrophages are believed to initiate these inflammatory responses, the mechanism by which this occurs has been unclear. Here we show...

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Autors principals: Cassel, Suzanne L., Eisenbarth, Stephanie C., Iyer, Shankar S., Sadler, Jeffrey J., Colegio, Oscar R., Tephly, Linda A., Carter, A. Brent, Rothman, Paul B., Flavell, Richard A., Sutterwala, Fayyaz S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449360/
https://ncbi.nlm.nih.gov/pubmed/18577586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803933105
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