The Nalp3 inflammasome is essential for the development of silicosis

Inhalation of crystalline silica and asbestos is known to cause the progressive pulmonary fibrotic disorders silicosis and asbestosis, respectively. Although alveolar macrophages are believed to initiate these inflammatory responses, the mechanism by which this occurs has been unclear. Here we show...

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Bibliografiska uppgifter
Huvudupphovsmän: Cassel, Suzanne L., Eisenbarth, Stephanie C., Iyer, Shankar S., Sadler, Jeffrey J., Colegio, Oscar R., Tephly, Linda A., Carter, A. Brent, Rothman, Paul B., Flavell, Richard A., Sutterwala, Fayyaz S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449360/
https://ncbi.nlm.nih.gov/pubmed/18577586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803933105
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