Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

The Na(+):K(+):2Cl(−) cotransporter (NKCC2) is the target of loop diuretics and is mutated in Bartter's syndrome, a heterogeneous autosomal recessive disease that impairs salt reabsorption in the kidney's thick ascending limb (TAL). Despite the importance of this cation/chloride cotranspor...

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Bibliographische Detailangaben
Hauptverfasser: Ponce-Coria, José, San-Cristobal, Pedro, Kahle, Kristopher T., Vazquez, Norma, Pacheco-Alvarez, Diana, de los Heros, Paola, Juárez, Patricia, Muñoz, Eva, Michel, Gabriela, Bobadilla, Norma A., Gimenez, Ignacio, Lifton, Richard P., Hebert, Steven C., Gamba, Gerardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2448858/
https://ncbi.nlm.nih.gov/pubmed/18550832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802966105
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