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Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to identify targets of palmitate in β-cell death. The most significantly altered protein in both human islets and MIN6 β-cells treated with palm...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2448857/ https://ncbi.nlm.nih.gov/pubmed/18550819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711232105 |
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