Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis

Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to identify targets of palmitate in β-cell death. The most significantly altered protein in both human islets and MIN6 β-cells treated with palm...

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Bibliographic Details
Main Authors: Jeffrey, Kristin D., Alejandro, Emilyn U., Luciani, Dan S., Kalynyak, Tatyana B., Hu, Xiaoke, Li, Hong, Lin, Yalin, Townsend, R. Reid, Polonsky, Kenneth S., Johnson, James D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2448857/
https://ncbi.nlm.nih.gov/pubmed/18550819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711232105
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