The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ

The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110α, p110β, and p110δ) occur in complex with a Src homology 2 (SH2) domain-containing p85 regulatory subunit, which has been shown to link p110α and p110δ to...

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Hlavní autoři: Guillermet-Guibert, Julie, Bjorklof, Katja, Salpekar, Ashreena, Gonella, Cristiano, Ramadani, Faruk, Bilancio, Antonio, Meek, Stephen, Smith, Andrew J. H., Okkenhaug, Klaus, Vanhaesebroeck, Bart
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2448830/
https://ncbi.nlm.nih.gov/pubmed/18544649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707761105
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