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The Critical Role of Substrate-Protein Hydrogen Bonding in the Control of Regioselective Hydroxylation in P450cin

Cytochrome P450cin (CYP176A1) is a bacterial P450 isolated from Citrobacter braakii that catalyzes the hydroxylation of cineole to (S)-6β-hydroxycineole. This initiates the biodegradation of cineole, enabling C. braakii to live on cineole as its sole source of carbon and energy. P450cin lacks the al...

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Detalhes bibliográficos
Main Authors: Meharenna, Yergalem T., Slessor, Kate E., Cavaignac, Sonia M., Poulos, Thomas L., De Voss, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447660/
https://ncbi.nlm.nih.gov/pubmed/18270198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709722200
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