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Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2

The nucleolar protein nucleostemin (NS) is essential for cell proliferation and early embryogenesis. Both depletion and overexpression of NS reduce cell proliferation. However, the mechanisms underlying this regulation are still unclear. Here, we show that NS regulates p53 activity through the inhib...

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Détails bibliographiques
Auteurs principaux: Dai, Mu-Shui, Sun, Xiao-Xin, Lu, Hua
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447154/
https://ncbi.nlm.nih.gov/pubmed/18426907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01662-07
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