Molecular mechanism of membrane targeting by the GRP1 PH domain

The general receptor for phosphoinositides isoform 1 (GRP1) is recruited to the plasma membrane in response to activation of phosphoinositide 3-kinases and accumulation of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)]. GRP1's pleckstrin homology (PH) domain recognizes PtdIns(3,4,...

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Main Authors: He, Ju, Haney, Rachel M., Vora, Mohsin, Verkhusha, Vladislav V., Stahelin, Robert V., Kutateladze, Tatiana G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2444010/
https://ncbi.nlm.nih.gov/pubmed/18469301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800150-JLR200
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