Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

Specific recognition of phosphatidylinositol 3-phosphate [PtdIns(3)P] by the FYVE domain targets cytosolic proteins to endosomal membranes during key signaling and trafficking events within eukaryotic cells. Here, we show that this membrane targeting is regulated by the acidic cellular environment....

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Bibliographic Details
Main Authors: Lee, Stephanie A., Eyeson, Rosemary, Cheever, Matthew L., Geng, Jinming, Verkhusha, Vladislav V., Burd, Christopher, Overduin, Michael, Kutateladze, Tatiana G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201587/
https://ncbi.nlm.nih.gov/pubmed/16141328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503900102
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