Evaluating the Effects of Imputation on the Power, Coverage, and Cost Efficiency of Genome-wide SNP Platforms

Genotype imputation is potentially a zero-cost method for bridging gaps in coverage and power between genotyping platforms. Here, we quantify these gains in power and coverage by using 1,376 population controls that are from the 1958 British Birth Cohort and were genotyped by the Wellcome Trust Case...

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Detalhes bibliográficos
Main Authors: Anderson, Carl A., Pettersson, Fredrik H., Barrett, Jeffrey C., Zhuang, Joanna J., Ragoussis, Jiannis, Cardon, Lon R., Morris, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2008
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443836/
https://ncbi.nlm.nih.gov/pubmed/18589396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.06.008
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