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Differential Roles for Checkpoint Kinases in DNA Damage-dependent Degradation of the Cdc25A Protein Phosphatase
In response to DNA damage, cells activate a signaling pathway that promotes cell cycle arrest and degradation of the cell cycle regulator Cdc25A. Cdc25A degradation occurs via the SCF(β-TRCP) pathway and phosphorylation of Ser-76. Previous work indicates that the checkpoint kinase Checkpoint kinase...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2443656/ https://ncbi.nlm.nih.gov/pubmed/18480045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802474200 |
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