Differential Roles for Checkpoint Kinases in DNA Damage-dependent Degradation of the Cdc25A Protein Phosphatase

In response to DNA damage, cells activate a signaling pathway that promotes cell cycle arrest and degradation of the cell cycle regulator Cdc25A. Cdc25A degradation occurs via the SCF(β-TRCP) pathway and phosphorylation of Ser-76. Previous work indicates that the checkpoint kinase Checkpoint kinase...

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Bibliographische Detailangaben
Hauptverfasser: Jin, Jianping, Ang, Xiaolu L., Ye, Xin, Livingstone, Mark, Harper, J. Wade
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443656/
https://ncbi.nlm.nih.gov/pubmed/18480045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802474200
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