PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells

BACKGROUND AND PURPOSE: Subtle changes in the intracellular reduction–oxidation (redox) state can modulate nuclear factor-κB (NF-κB) activity. Thioredoxin-1 (Trx) is a small, ubiquitous, redox-active thiol (-SH) protein that, with thioredoxin reductase-1 (TrxR), modifies the redox status of NF-κB pa...

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Detalhes bibliográficos
Main Authors: Callister, M E, Pinhu, L, Catley, M C, Westwell, A D, Newton, R, Leaver, S K, Quinlan, G J, Evans, T W, Griffiths, M J, Burke-Gaffney, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442904/
https://ncbi.nlm.nih.gov/pubmed/18587424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.258
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