Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study

AW464 (NSC 706704) is a novel benzothiazole substituted quinol compound active against colon, renal and certain breast cancer cell lines. NCI COMPARE analysis indicates possible interaction with thioredoxin/thioredoxin reductase, which is upregulated under hypoxia. Through activity on HIF1α, VEGF le...

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Detalhes bibliográficos
Main Authors: Mukherjee, A, Westwell, A D, Bradshaw, T D, Stevens, M F G, Carmichael, J, Martin, S G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361836/
https://ncbi.nlm.nih.gov/pubmed/15655539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602338
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