Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been associated with systemic lupus erythematosus (SLE). FcγRIIIb is a glycosylphosphatidylinositol-linke...

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Bibliographic Details
Main Authors: Willcocks, Lisa C., Lyons, Paul A., Clatworthy, Menna R., Robinson, James I., Yang, Wanling, Newland, Stephen A., Plagnol, Vincent, McGovern, Naomi N., Condliffe, Alison M., Chilvers, Edwin R., Adu, Dwomoa, Jolly, Elaine C., Watts, Richard, Lau, Yu Lung, Morgan, Ann W., Nash, Gerard, Smith, Kenneth G.C.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Brief Definitive Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442635/
https://ncbi.nlm.nih.gov/pubmed/18559452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072413
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