Copy number, linkage disequilibrium and disease association in the FCGR locus

The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of IgG (FcγRs), and alterations in their affinity or function have been associated with risk of autoimmune diseases, including systemic lupus erythematosus (SLE). The low-affinity FcγR genomic locus is...

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Bibliographic Details
Main Authors: Niederer, Heather A., Willcocks, Lisa C., Rayner, Tim F., Yang, Wanling, Lau, Yu Lung, Williams, Thomas N., Scott, J. Anthony G., Urban, Britta C., Peshu, Norbert, Dunstan, Sarah J., Hien, Tran Tinh, Phu, Nguyen Hoan, Padyukov, Leonid, Gunnarsson, Iva, Svenungsson, Elisabet, Savage, Caroline O., Watts, Richard A., Lyons, Paul A., Clayton, David G., Smith, Kenneth G.C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Association Studies Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908468/
https://ncbi.nlm.nih.gov/pubmed/20508037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq216
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