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The Role of Lipophilicity in Determining Binding Affinity and Functional Activity for 5-HT(2A) Receptor Ligands
The lipophilicity of a set of 5-HT(2A) ligands was determined using immobilized-artificial-membrane chromatography, a method that generates values well-correlated with octanol-water partition coefficients. For agonists, a highly significant linear correlation was observed between binding affinity an...
Gorde:
| Egile Nagusiak: | , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442558/ https://ncbi.nlm.nih.gov/pubmed/18296055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.02.033 |
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