A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis

The human suppressor of morphogenesis in genitalia-1 (hSMG-1) protein kinase plays dual roles in mRNA surveillance and genotoxic stress response pathways in human cells. Here, we report that small interfering RNA-mediated depletion of hSMG-1, but not ATM, ATR, hUpf1, or hUpf2, in human U2OS osteosar...

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Detalhes bibliográficos
Main Authors: Oliveira, Vasco, Romanow, William J., Geisen, Christoph, Otterness, Diane M., Mercurio, Frank, Wang, Hong Gang, Dalton, William S., Abraham, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442360/
https://ncbi.nlm.nih.gov/pubmed/18326048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708008200
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