Cytoplasmic Terminus of Vacuolar Type Proton Pump Accessory Subunit Ac45 Is Required for Proper Interaction with V(0) Domain Subunits and Efficient Osteoclastic Bone Resorption

Solubilization of mineralized bone by osteoclasts is largely dependent on the acidification of the extracellular resorption lacuna driven by the vacuolar (H+)-ATPases (V-ATPases) polarized within the ruffled border membranes. V-ATPases consist of two functionally and structurally distinct domains, V...

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Detalhes bibliográficos
Main Authors: Feng, Haotian, Cheng, Taksum, Pavlos, Nathan J., Yip, Kirk H. M., Carrello, Amerigo, Seeber, Ruth, Eidne, Karin, Zheng, Ming H., Xu, Jiake
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442344/
https://ncbi.nlm.nih.gov/pubmed/18227071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709712200
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