Cytoplasmic Terminus of Vacuolar Type Proton Pump Accessory Subunit Ac45 Is Required for Proper Interaction with V(0) Domain Subunits and Efficient Osteoclastic Bone Resorption

Solubilization of mineralized bone by osteoclasts is largely dependent on the acidification of the extracellular resorption lacuna driven by the vacuolar (H+)-ATPases (V-ATPases) polarized within the ruffled border membranes. V-ATPases consist of two functionally and structurally distinct domains, V...

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Hlavní autoři: Feng, Haotian, Cheng, Taksum, Pavlos, Nathan J., Yip, Kirk H. M., Carrello, Amerigo, Seeber, Ruth, Eidne, Karin, Zheng, Ming H., Xu, Jiake
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Membrane Transport, Structure, Function, and Biogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442344/
https://ncbi.nlm.nih.gov/pubmed/18227071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709712200
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