Calcium Binding Rigidifies the C2 Domain and the Intradomain Interaction of GIVA Phospholipase A(2) as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

The GIVA phospholipase A(2) (PLA(2)) contains two domains: a calcium-binding domain (C2) and a catalytic domain. These domains are linked via a flexible tether. GIVA PLA(2) activity is Ca(2+)-dependent in that calcium binding promotes protein docking to the phospholipid membrane. In addition, the ca...

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Bibliographic Details
Main Authors: Hsu, Yuan-Hao, Burke, John E., Stephens, Daren L., Deems, Raymond A., Li, Sheng, Asmus, Kyle M., Woods, Virgil L., Dennis, Edward A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442293/
https://ncbi.nlm.nih.gov/pubmed/18211893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708143200
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