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Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity
β-Catenin functions in both cell–cell adhesion and as a transcriptional coactivator in the canonical Wnt pathway. Nuclear accumulation of β-catenin is the hallmark of active Wnt signaling and is frequently observed in human cancers. Although β-catenin shuttles in and out of the nucleus, the molecula...
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| Главные авторы: | , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442201/ https://ncbi.nlm.nih.gov/pubmed/18573912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200709091 |
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