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Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity

β-Catenin functions in both cell–cell adhesion and as a transcriptional coactivator in the canonical Wnt pathway. Nuclear accumulation of β-catenin is the hallmark of active Wnt signaling and is frequently observed in human cancers. Although β-catenin shuttles in and out of the nucleus, the molecula...

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Autori principali: Li, Feng-Qian, Mofunanya, Adaobi, Harris, Kimberley, Takemaru, Ken-Ichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442201/
https://ncbi.nlm.nih.gov/pubmed/18573912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200709091
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