The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc(Min/+ )mouse small intestine

BACKGROUND: Alterations in gene splicing occur in human sporadic colorectal cancer (CRC) and may contribute to tumour progression. The K-ras proto-oncogene encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in CRC. Past studi...

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Detalhes bibliográficos
Main Authors: Patek, Charles E, Arends, Mark J, Rose, Lorraine, Luo, Feijun, Walker, Marion, Devenney, Paul S, Berry, Rachel L, Lawrence, Nicola J, Ridgway, Rachel A, Sansom, Owen J, Hooper, Martin L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442095/
https://ncbi.nlm.nih.gov/pubmed/18554389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-8-24
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