Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteolytic activity. Calpains have been linked to the modulation of memory and are key to the pathogenesis of Alzheimer disease (AD). When abnormally activated, calpains can also initiate degradation of pro...

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Detalhes bibliográficos
Main Authors: Trinchese, Fabrizio, Fa’, Mauro, Liu, Shumin, Zhang, Hong, Hidalgo, Ariel, Schmidt, Stephen D., Yamaguchi, Hisako, Yoshii, Narihiko, Mathews, Paul M., Nixon, Ralph A., Arancio, Ottavio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441853/
https://ncbi.nlm.nih.gov/pubmed/18596919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34254
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