Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteolytic activity. Calpains have been linked to the modulation of memory and are key to the pathogenesis of Alzheimer disease (AD). When abnormally activated, calpains can also initiate degradation of pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Trinchese, Fabrizio, Fa’, Mauro, Liu, Shumin, Zhang, Hong, Hidalgo, Ariel, Schmidt, Stephen D., Yamaguchi, Hisako, Yoshii, Narihiko, Mathews, Paul M., Nixon, Ralph A., Arancio, Ottavio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441853/
https://ncbi.nlm.nih.gov/pubmed/18596919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34254
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