Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

Learning and memory and the underlying cellular correlate, long-term synaptic plasticity, involve regulation by posttranslational modifications (PTMs). Here we demonstrate that conjugation with the small ubiquitin-like modifier (SUMO) is a novel PTM required for normal synaptic and cognitive functio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lee, Linda, Dale, Elena, Staniszewski, Agnes, Zhang, Hong, Saeed, Faisal, Sakurai, Mikako, Fa', Mauro, Orozco, Ian, Michelassi, Francesco, Akpan, Nsikan, Lehrer, Helena, Arancio, Ottavio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250909/
https://ncbi.nlm.nih.gov/pubmed/25448527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07190
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