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The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53

BACKGROUND: The vaccinia-related kinase 1 (VRK1) protein, an activator of p53, can be proteolytically downregulated by an indirect mechanism, which requires p53-dependent transcription. PRINCIPAL FINDINGS: In this work we have biochemically characterized the contribution of several p53 transcription...

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Bibliografski detalji
Glavni autori: Valbuena, Alberto, Blanco, Sandra, Vega, Francisco M., Lazo, Pedro A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441436/
https://ncbi.nlm.nih.gov/pubmed/18612383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002649
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