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p53 Downregulates Its Activating Vaccinia-Related Kinase 1, Forming a New Autoregulatory Loop
The stable accumulation of p53 is detrimental to the cell because it blocks cell growth and division. Therefore, increases in p53 levels are tightly regulated, mainly by its transcriptional target, mdm2, that downregulates p53. Elucidation of new signaling pathways requires the characterization of t...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1489172/ https://ncbi.nlm.nih.gov/pubmed/16782868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00069-06 |
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