Autoreactive Human TCR Initiate Insulitis and Impaired Glucose Tolerance in HLA DR4 Transgenic Mice

A human TcR derived from an autoreactive T cell specific for GAD65, from a subject at high risk for autoimmune diabetes, was introduced into HLA-DR4 transgenic mice. The source of TCR was a CD4(+) T(H)1(+)T cell clone which responded to an immunodominant epitope of the human islet protein GAD65, an...

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Hlavní autoři: Gebe, John A., Unrath, Kellee A., Yue, Betty B., Miyake, Tom, Falk, Ben A., Nepom, Gerald T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440666/
https://ncbi.nlm.nih.gov/pubmed/17949947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2007.08.001
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