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Autoreactive Human TCR Initiate Insulitis and Impaired Glucose Tolerance in HLA DR4 Transgenic Mice
A human TcR derived from an autoreactive T cell specific for GAD65, from a subject at high risk for autoimmune diabetes, was introduced into HLA-DR4 transgenic mice. The source of TCR was a CD4(+) T(H)1(+)T cell clone which responded to an immunodominant epitope of the human islet protein GAD65, an...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440666/ https://ncbi.nlm.nih.gov/pubmed/17949947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2007.08.001 |
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