Age-Dependent Loss of Tolerance to an Immunodominant Epitope of Glutamic Acid Decarboxylase in Diabetic prone RIP-B7/DR4 Mice

We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in RIP-B7/DRB1(*)0404 HLA transgenic mice. Diabetic an...

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Detalhes bibliográficos
Main Authors: Gebe, John A., Unrath, Kellee A, Falk, Ben A., Ito, Kouichi, Wen, Li, Daniels, Terri L., Lernmark, Åke, Nepom, Gerald T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850983/
https://ncbi.nlm.nih.gov/pubmed/16979383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2006.08.002
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