Homo-oligomerization Is Essential for Toll/Interleukin-1 Receptor Domain-containing Adaptor Molecule-1-mediated NF-κB and Interferon Regulatory Factor-3 Activation

Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (TICAM-1, also named TIR domain-containing adaptor-inducing interferon (IFN)-β or TRIF)) is a signaling adaptor of Toll-like receptor (TLR) 3/4 that activates the transcription factors, interferon regulatory factor-3 (IRF-3) and NF-κB lea...

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Bibliographic Details
Main Authors: Funami, Kenji, Sasai, Miwa, Oshiumi, Hiroyuki, Seya, Tsukasa, Matsumoto, Misako
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440629/
https://ncbi.nlm.nih.gov/pubmed/18450748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801013200
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