A Molecular Mechanism for Toll-IL-1 Receptor Domain-containing Adaptor Molecule-1-mediated IRF-3 Activation

The Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (TICAM-1, also called TRIF) is a signaling adaptor for TLR3 and TLR4 that activates the transcription factors IRF-3, NF-κB, and AP-1, leading to induction of type I interferon and cytokines. The N-terminal region of TICAM-1 participat...

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Bibliografische gegevens
Hoofdauteurs: Tatematsu, Megumi, Ishii, Akihiro, Oshiumi, Hiroyuki, Horiuchi, Masataka, Inagaki, Fuyuhiko, Seya, Tsukasa, Matsumoto, Misako
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2010
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888425/
https://ncbi.nlm.nih.gov/pubmed/20418377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.099101
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