Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling

Homotypic and heterotypic interactions between Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors (TLRs) and downstream adaptors are essential to evoke innate immune responses. However, such oligomerization properties present intrinsic difficulties in structural studies of TIR domains....

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Hauptverfasser: Enokizono, Yoshiaki, Kumeta, Hiroyuki, Funami, Kenji, Horiuchi, Masataka, Sarmiento, Joy, Yamashita, Kazuo, Standley, Daron M., Matsumoto, Misako, Seya, Tsukasa, Inagaki, Fuyuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856793/
https://ncbi.nlm.nih.gov/pubmed/24255114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222811110
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